Co‑expression of cancer‑testis antigens of MAGE‑A6 and MAGE‑A11 is associated with tumor aggressiveness in patients with bladder cancer
Melanoma antigen gene (MAGE)-A6 and MAGE-A11 are two of the most cancer-testis antigens
overexpressed in various types of cancers. However, the clinical and prognosis value of MAGE-A6
and MAGE-A11 co-expression in the pathophysiology of the bladder is unknown. Three studies were
selected from GEO databases in order to introduce the common genes that are involved in bladder
cancer. Then immunohistochemical analysis for staining pattern and clinicopathological significance
of suggested markers, MAGE-A6 and MAGE-A11, were performed in 199 and 213 paraffin-embedded
bladder cancer with long adjacent normal tissues, respectively. A significant and positive correlation
was found between both nuclear and cytoplasmic expressions of MAGE-A6 as well as expression of
cytoplasmic MAGE-A11 with histological grade, PT stage, lamina propria invasion, and LP/ muscularis
(L/M) involvement (all of the p-values in terms of H-score were < 0.0001). Additionally, significant
differences were found between both nuclear and cytoplasmic MAGE-A6/MAGE-A11 phenotypes with
tumor size (P = 0.007, P = 0.043, respectively), different histological grades, PT stage, LP involvement,
and L/M involvement (all of the p-values for both phenotypes were < 0.0001). The current study added
the value of these novel markers to the bladder cancer clinical settlement that might be considered as
an admirable target for immunotherapy.
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